lipedema rss lipedema rss: Latest results from PubMed

  • Lipedema and the Potential Role of Estrogen in Excessive Adipose Tissue Accumulation
    by Kaleigh Katzer on 13 de novembro de 2021 at 11:00

    Lipedema is a painful fat disorder that affects ~11% of the female population. It is characterized by bilateral, disproportionate accumulation of subcutaneous adipose tissue predominantly in the lower body. The onset of lipedema pathophysiology is thought to occur during periods of hormonal fluctuation, such as puberty, pregnancy, or menopause. Although the identification and characterization of lipedema have improved, the underlying disease etiology remains to be elucidated. Estrogen, a key…

  • Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema
    by Musarat Ishaq on 12 de novembro de 2021 at 11:00

    CONCLUSION: We found significant differences in gene expression, and lipid and metabolite profiles, in tissue, ADSCs, and adipocytes from lipedema patients compared to non-affected controls. Functional assays demonstrated that dysregulated Bub1 signaling drives increased proliferation of lipedema ADSCs, suggesting a potential mechanism for enhanced adipogenesis in lipedema. Importantly, our characterization of signaling networks driving lipedema identifies potential molecular targets, including…

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  • Physical Therapy in Women with Early Stage Lipedema: Potential Impact of Multimodal Manual Therapy, Compression, Exercise, and Education Interventions
    by Paula M C Donahue on 8 de novembro de 2021 at 11:00

    Background: Lipedema is a distinct adipose disorder from obesity necessitating awareness as well as different management approaches to address pain and optimize quality of life (QoL). The purpose of this proof-of-principle study is to evaluate the therapeutic potential of physical therapy interventions in women with lipedema. Methods and Results: Participants with Stage 1-2 lipedema and early Stage 0-1 lymphedema (n = 5, age = 38.4 ± 13.4 years, body mass index = 27.2 ± 4.3 kg/m²) underwent nine…

  • A randomised controlled multicentre investigator-blinded clinical trial comparing efficacy and safety of surgery versus complex physical decongestive therapy for lipedema (LIPLEG)
    by Maurizio Podda on 31 de outubro de 2021 at 10:00

    BACKGROUND: Lipedema is a chronic disorder of the adipose tissue that affects mainly women, characterised by symmetrical, excessive fatty tissue on the legs and pain. Standard conservative treatment is long-term comprehensive decongestive therapy (CDT) to alleviate lipedema-related pain and to improve psychosocial well-being, mobility and physical activity. Patients may benefit from surgical removal of abnormally propagated adipose tissue by liposuction. The LIPLEG trial evaluates the efficacy…

  • Crosstalk Between Adipose and Lymphatics in Health and Disease
    by Gregory P Westcott on 31 de outubro de 2021 at 10:00

    Adipose tissue, once thought to be an inert receptacle for energy storage, is now recognized as a complex tissue with multiple resident cell populations that actively collaborate in response to diverse local and systemic metabolic, thermal, and inflammatory signals. A key participant in adipose tissue homeostasis that has only recently captured broad scientific attention is the lymphatic vasculature. The lymphatic system’s role in lipid trafficking and mediating inflammation makes it a natural…

  • Elevated magnetic resonance imaging measures of adipose tissue deposition in women with breast cancer treatment-related lymphedema
    by Rachelle Crescenzi on 23 de outubro de 2021 at 10:00

    CONCLUSION: Adiposity quantified by MRI is elevated in the affected upper extremity of women with BCRL and may provide a surrogate marker of condition onset or severity.

  • Unique functions for Notch4 in murine embryonic lymphangiogenesis
    by Ajit Muley on 19 de outubro de 2021 at 10:00

    In mice, embryonic dermal lymphatic development is well understood and used to study gene functions in lymphangiogenesis. Notch signaling is an evolutionarily conserved pathway that modulates cell fate decisions, which has been shown to both inhibit and promote dermal lymphangiogenesis. Here, we demonstrate distinct roles for Notch4 signaling versus canonical Notch signaling in embryonic dermal lymphangiogenesis. Actively growing embryonic dermal lymphatics expressed NOTCH1, NOTCH4, and DLL4…

  • Lipedema in a male patient: report of a rare case – management and review of the literature
    by Mattis Bertlich on 18 de outubro de 2021 at 10:00

    Objective: Lipedema is a relatively common yet debilitating and often misdiagnosed lipodystrophy that mainly affects females. Very little is known about the etiology and pathophysiology of the disease. However, due to its high preference for female patients, hormonal factors may contribute to the pathogenesis. Case: A 62-year-old male patient presented to the authors with painful swelling of the thighs. The patient had been treated elsewhere for lymphedema with subsequent disease progression….

  • Lipoedema as a Social Problem. A Scoping Review
    by Monika Czerwińska on 13 de outubro de 2021 at 10:00

    (1) Background: Lipoedema is a disease characterized by excessive bilateral and symmetrical accumulation of subcutaneous tissue in the lower extremities. It is a poorly understood condition, and low awareness of its existence often leads to incorrect diagnosis Initially, lipoedema was considered to be completely independent of lifestyle Currently, however, more and more cases of the coexistence of lipoedema and obesity are described in the literature as additionally affecting the severity of the…

  • Common and Contrasting Characteristics of the Chronic Soft-Tissue Pain Conditions Fibromyalgia and Lipedema
    by Felix Angst on 24 de setembro de 2021 at 10:00

    OBJECTIVE: To examine the common and specific characteristics of fibromyalgia and lipedema, two chronic soft-tissue pain syndromes without curative therapy options.

    by U Wollina on 13 de setembro de 2021 at 10:00

    Both lipedema and juxta-articular adiposis dolorsa are painful disorders of subcutaneous adipose tissue. We investigated 297 female patients with lipedema treated at our department for the presence of juxta-articular adiposis dolorsa. Occurrence of both disorders was identified in 4.4% of lipedema patients. The common presence of both disorders was observed only in more advanced lipedema (grade II and III). Juxta-articular adiposis dolorosa of the knees is seen exclusively on the inner knees,…

  • The association between serum vitamin D and mood disorders in a cohort of lipedema patients
    by Mohammad Al-Wardat on 29 de julho de 2021 at 10:00

    CONCLUSIONS: This study suggests a strong correlation between Vit. D levels, depression scores, and anxiety scores in lipedema patients. Our results also demonstrate a strong and direct relationship between BMI, Vit. D levels, depression, and anxiety.

  • Leg Volume in Patients with Lipoedema following Bariatric Surgery
    by Jodok M Fink on 12 de julho de 2021 at 10:00

    CONCLUSION: SG and RYGB lead to a significant thigh volume reduction in patients with lipoedema.

  • Women’s experiences of living with lipedema
    by Catharina Melander on 12 de julho de 2021 at 10:00

    Lipedema is a chronic, progressive disease that almost exclusively affects women and often misdiagnosed as obesity or primary lymphedema. Research concerning lipedema is sparse, and there is a lack of studies focusing on women’s experiences of living with the illness. We interviewed fourteen women with lipedema with the aim of describing their experiences of living with lipedema. Our results show that women felt controlled by their body, and were fat-shamed and viewed by others as a person who…

  • Development of a questionnaire and screening model for lipedema
    by Alexandre Campos Moraes Amato on 2 de julho de 2021 at 10:00

    CONCLUSIONS: The lipedema screening questionnaire is a practical instrument that is quick and easy to administer and can be used with our population for identification of possible lipedema patients, raising the level of suspicion when taking a patient’s history and conducting a physical examination.

  • Translation, cultural adaptation, and validation of a lipedema symptoms questionnaire
    by Alexandre Campos Moraes Amato on 28 de junho de 2021 at 10:00

    CONCLUSIONS: The translated and culturally adapted Brazilian Portuguese version of the lipedema symptoms assessment questionnaire (QuASiL) is a practical tool that is easy and quick to administer and can be used in our population. Additional studies are still needed to assess the instrument’s sensitivity as an aid for diagnosis of lipedema.

  • A Young Woman with Excessive Fat in Lower Extremities Develops Disordered Eating and Is Subsequently Diagnosed with Anorexia Nervosa, Lipedema, and Hypermobile Ehlers-Danlos Syndrome
    by Thomas F Wright on 14 de junho de 2021 at 10:00

    BACKGROUND Lipedema is a loose connective tissue disease that causes disproportionate subcutaneous fat accumulation on the extremities. As a result of the increased subcutaneous tissue accumulation, lipedema is often confused with obesity by both physicians and patients. Poor awareness and limited diagnosis of lipedema contribute to the confusion of lipedema with obesity and can lead to decreased body image acceptance. Patients with lipedema may have anorexia nervosa, an eating disorder…

  • Standard of care for lipedema in the United States
    by Karen L Herbst on 29 de maio de 2021 at 10:00

    CONCLUSION: These guidelines improve the understanding of the loose connective tissue disease, lipedema, to advance our understanding towards early diagnosis, treatments, and ultimately a cure for affected individuals.

  • A 41-Year-Old Woman with Excessive Fat of the Lower Body Since Puberty with Progression to Swollen Ankles and Feet Despite Caloric Restriction, Due to Lipedema and Protein-Calorie Malnutrition: A Case of Stage 3 Lipedema
    by Thomas F Wright on 7 de maio de 2021 at 10:00

    BACKGROUND Lipedema is a common condition that presents as excessive fat deposition in the extremities, initially sparing the trunk, ankles, and feet, and is found mainly in women, usually occurring after puberty or pregnancy. Lipedema can progress to include lipo-lymphedema of the ankles and feet. This report is of a 41-year old woman with Stage 3 lipedema and lipo-lymphedema with excessive fat of the lower body since puberty, with progression to swollen ankles and feet despite dietary caloric…

  • Liposuction treatment improves disease-specific quality of life in lipoedema patients
    by Torsten Schlosshauer on 6 de maio de 2021 at 10:00

    This study examined the disease-specific quality of life (QoL) in lipoedema patients undergoing treatment for the condition with liposuction. We conducted a retrospective analysis of all patients (n = 69) who underwent liposuction for treatment of lipoedema between 2004 and 2019, and gathered data on patient age, body mass index, the number of liposuction sessions, and the amount of fat removed per side. The study also prospectively evaluated the QoL in 20 lipoedema patients before and after…

  • Survey Outcomes of Lipedema Reduction Surgery in the United States
    by Karen L Herbst on 29 de abril de 2021 at 10:00

    CONCLUSIONS: Women with lipedema noticed significant benefits after lipedema reduction surgery in the USA. Prospective studies are needed to assess benefits and complications after lipedema reduction surgery in the USA.

  • Choroid plexus perfusion in sickle cell disease and moyamoya vasculopathy: Implications for glymphatic flow
    by Skylar E Johnson on 28 de abril de 2021 at 10:00

    Cerebrospinal fluid (CSF) and interstitial fluid exchange have been shown to increase following pharmacologically-manipulated increases in cerebral arterial pulsatility, consistent with arterial pulsatility improving CSF circulation along perivascular glymphatic pathways. The choroid plexus (CP) complexes produce CSF, and CP activity may provide a centralized indicator of perivascular flow. We tested the primary hypothesis that elevated cortical cerebral blood volume and flow, present in sickle…

  • Correction to: The Effects of Complex Decongestive Physiotherapy Applications on Lower Extremity Circumference and Volume in Patients with Lipedema by Volkan-Yazici, et al. Lymphat Res Biol 2021;19(1):111-114; DOI: 10.1089/lrb.2020.0080
    on 26 de abril de 2021 at 10:00

    No abstract

  • Update in the management of lipedema
    by Isabel Forner-Cordero on 19 de abril de 2021 at 10:00

    CONCLUSIONS: The setting of realistic expectations is important for both patient and medical care provider. The major aims of the management are multimodal for improvements in the quality of life; reduction in heaviness and pain, reshaping the affected limbs, weight control, improvements in mobility. Compression garments, physical therapy, exercise regimens, diet and psychological counseling are necessities. For selected patients, surgical treatment is an added option.

  • Ultrasound criteria for lipedema diagnosis
    by Alexandre Campos Moraes Amato on 15 de abril de 2021 at 10:00

    CONCLUSIONS: Studied criteria allow use of simple and reproducible ultrasound cutoff values to diagnose lipedema in the lower limbs. Pre-tibial region thickness measurement, followed by thigh and lateral leg thickness are recommended for the ultrasound diagnosis of lipedema.

  • Management of large volume liposuction in lipedema patients with von Willebrand disease: A systematic review and treatment algorithm
    by Jeremias Schmidt on 5 de abril de 2021 at 10:00

    CONCLUSION: The implementation of the developed diagnostic and treatment algorithm may help further reducing bleeding complications and improve the safety for treated patients.

  • A Distinct Cytokine Profile and Stromal Vascular Fraction Metabolic Status without Significant Changes in the Lipid Composition Characterizes Lipedema
    by Stefan Wolf on 3 de abril de 2021 at 10:00

    Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat tissue in the lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish the disease exist, leading to a large number of undiagnosed and misdiagnosed patients. To unravel the distinct molecular characteristic of lipedema we performed lipidomic analysis of the adipose tissue and serum of lipedema versus anatomically- and body mass…

  • Reducing Circumference and Volume in Upper Extremity Lipedema: The Role of Complex Decongestive Physiotherapy
    by Melek Volkan-Yazici on 2 de abril de 2021 at 10:00

    Objective: The aim of this study is to investigate the effect of complex decongestive physiotherapy (CDP) plus intermittent pneumatic compression (IPC) applications on upper extremity circumference and volume in patients with lipedema. Methods and Results: All participants included in the study were included in a treatment protocol consisting of CDP and IPC. The Perometer 400 NT was used in the measurement of upper extremity volume and circumference before and after treatment. The measurements…

  • Lipedema : an unknown entity
    by Vincienne Naef on 1 de abril de 2021 at 10:00

    Lipedema is an infrequently recognized disorder. It is characterized by bilateral painful enlargement of the legs due to abnormal depositions of subcutaneous fat, that can result in considerable disability. The diagnosis is established on the basis of medical history and clinical findings. Early diagnosis of this disorder is necessary to start adapted management and prevent progression and complications of the disease. Currently there is no curative treatment. The conservative treatment requires…

  • Interstitial Fluid in Lipedema and Control Skin
    by Marisol Allen on 31 de março de 2021 at 10:00

    Background: Fluid in lymphedema tissue appears histologically as spaces around vessels and between dermal skin fibers. Lipedema is a painful disease of excess loose connective tissue (fat) in limbs, almost exclusively of women, that worsens by stage, increasing lymphedema risk. Many women with lipedema have hypermobile joints suggesting a connective tissue disorder that may affect vessel structure and compliance of tissue resulting in excess fluid entering the interstitial space. It is unclear…

  • The Prevalence Was Probably Overestimated
    by Ulrich Herpertz on 24 de março de 2021 at 10:00

    No abstract

  • Stemmer Sign Needs to be Recorded and Interpreted Correctly
    by Wolfgang Justus Brauer on 24 de março de 2021 at 10:00

    No abstract

  • Lipoedema: a paradigm shift and consensus. Has a consensus been achieved?
    by Leslyn Keith on 17 de março de 2021 at 10:00

    No abstract

  • Response from the authors…
    by Tobias Bertsch on 17 de março de 2021 at 10:00

    No abstract

  • High Volume Liposuction in Tumescence Anesthesia in Lipedema Patients: A Retrospective Analysis
    by Matthias Sandhofer on 8 de março de 2021 at 11:00

    Lipedema is a chronic, progressive disease that occurs almost exclusively in women and leads to pathological, painful fat growths at the extremities. Only symptomatic therapy can be offered since the etiology of the disease has not yet been clarified. Liposuction in tumescent anesthesia has established itself as a surgical treatment method of choice. The complication rate associated with the procedure and the pharmacological course and safety of treatment in patients with lipedema has not yet…

  • Rest/stress intradermal lymphoscintigraphy in diagnosis of lipedema
    by Girolamo Tartaglione on 24 de fevereiro de 2021 at 11:00

    Lipedema is a chronic and progressive disease characterized by a symmetrical and bilateral swelling of the lower extremities. In general, the feet are not involved. Lipedema is believed to affect nearly 1 in 9 adult women worldwide. Despite this relatively common disease, lipedema is often confused with primary lymphedema or obesity. In clinically advanced lipedema stages, fat continues to build up and may block the lymphatic vessels causing a secondary lymphedema (Lipo-Lymphedema). We…

  • Lipolymph node presenting as a pulmonary nodule: A case report
    by Yan Huang on 11 de fevereiro de 2021 at 11:00

    A 53-year-old man was admitted to our hospital with a history of a right lung nodule which had gradually increased in size. Wedge resection of the right middle lobe using video-assisted thoracoscopic surgery (VATS) was performed and revealed a yellowish, soft, well circumscribed nodule. Histological analysis confirmed the diagnosis of an uncommon lipolymph node. The patient recovered well from surgery, and there has been no recurrence in the lung for over one-year of follow-up. To the best of…

  • Establishing Standards for Centers of Excellence for the Diagnosis and Treatment of Lymphatic Disease
    by David Chang on 5 de fevereiro de 2021 at 11:00

    Background: Lymphatic disease patients make up a significant proportion of the US and world populations. Due to inadequate medical school training and underestimation of the impact of lymphatic circulation, lymphatic disease patients often have difficulty finding competent diagnosis and care. Methods and Results: The Lymphatic Education & Research Network has initiated a Centers of Excellence program to designate institutions that provide services for lymphatic disease patients. Committees of…

  • Potential Effects of a Modified Mediterranean Diet on Body Composition in Lipoedema
    by Laura Di Renzo on 28 de janeiro de 2021 at 11:00

    Lipoedema is a subcutaneous adipose tissue disease characterized by the increase in the amount and structure of fat mass (FM) in specific areas, causing pain and discomfort. 95% of patients fail to lose weight in the lipoedema areas. The study was conducted to evaluate body composition and general health status modification in a group of lipoedema patients (LIPPY) and a control group (CTRL) after four weeks of a modified Mediterranean diet therapy (mMeD). A total of 29 subjects were included in…

  • Diagnosis and treatment of lipedema in Spain. Results of an online survey
    by E Vaquero Ramiro on 19 de janeiro de 2021 at 11:00

    CONCLUSIONS: Currently, there is no standard treatment for lipedema and patients perceive current treatments to be unsatisfactory. Better knowledge of this entity is needed to allow early diagnosis and provide adequate treatment.

  • Quality of life, its factors, and sociodemographic characteristics of Polish women with lipedema
    by Joanna E Dudek on 15 de janeiro de 2021 at 11:00

    CONCLUSIONS: The current study provides initial information on screening questions, lipedema symptoms, and comorbidities, pointing to the areas needing in-depth investigation. Further steps to improve quality of life in women with lipedema and to reduce health costs should include the education of medical health professionals, using diagnostic tools that allow for differentiation among diagnoses and precise health risk assessment, and creating Polish treatment guidelines for lipedema.

  • Primary lymphedema French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins)
    by Stéphane Vignes on 7 de janeiro de 2021 at 11:00

    Primary lymphedema is a rare chronic pathology associated with constitutional abnormalities of the lymphatic system. The objective of this French National Diagnosis and Care Protocol (Protocole National de Diagnostic et de Soins; PNDS), based on a critical literature review and multidisciplinary expert consensus, is to provide health professionals with an explanation of the optimal management and care of patients with primary lymphedema. This PNDS, written by consultants at the French National…

  • Lipedema
    by Ankit Vyas on 1 de janeiro de 2021 at 11:00

    Dr. Allen and Dr. Hines pioneered and first described lipedema in the 1940s, a common subcutaneous adipose tissue disorder characterized as enlargement of both lower extremities. Lipedema is not edema; it is a genetically determined disturbance in adipose tissue mass and adipose tissue distribution. In 1951 a second seminal paper provided more description of lipedema. Fat distribution involves lower extremities, upper arms, hips, buttocks, thighs sparing trunks, and feet. Lower extremities are…

  • Unpreserved Lymphatic Reserve in Heart Failure With Preserved Ejection Fraction
    by Deepak K Gupta on 11 de dezembro de 2020 at 11:00

    No abstract

  • Ketogenic diet as a potential intervention for lipedema
    by L Keith on 11 de dezembro de 2020 at 11:00

    Lipedema (LI) is a common yet misdiagnosed condition, often misconstrued with obesity. LI affects women almost exclusively, and its painful and life-changing symptoms have long been thought to be resistant to the lifestyle interventions such as diet and exercise. In this paper, we discuss possible mechanisms by which patients adopting a ketogenic diet (KD) can alleviate many of the unwanted clinical features of LI. This paper is also an effort to provide evidence for the hypothesis of the…

  • The Effects of Complete Decongestive Therapy or Intermittent Pneumatic Compression Therapy or Exercise Only in the Treatment of Severe Lipedema: A Randomized Controlled Trial
    by Tuğba Atan on 10 de dezembro de 2020 at 11:00

    Background: Lack of diagnostic awareness of lipedema and frequent confusion with obesity or lymphedema may be an obstacle for treatment. The clinical effects of conservative treatment methods are not clearly known. This study investigated the effects of exercise-based rehabilitation combined with complete decongestive therapy (CDT) or intermittent pneumatic compression therapy (IPCT) or alone in patients with severe lipedema. Methods: Thirty-three women with severe (type 3, stage III or IV)…

  • Hematoma in lipedema: from cutaneous origin or defect of coagulation?
    by Christoph Sucker on 10 de dezembro de 2020 at 11:00

    Lipedema is a widespread in concern of etiology partially unknown disease especially in women. In many cases it is accompanied by bleeding complications. Our current work focuses on possible coagulation disorders as potential sources of such bleeding complications. Since only a minority of our patients showed a coagulation defect it is suggestive that the main underlying reason for bleeding in lipedema is of cutaneous origin what may only be forwarded by simultaneously existing coagulation…

  • Current review of factors in the stem cell donor that influence the regenerative potential of adipose tissue-derived stem cells
    by Constanze Kuhlmann on 8 de dezembro de 2020 at 11:00

    CONCLUSION: We recommend characterisation of the ASC donor cohort in all publications, regardless of whether they are experimental studies or clinical trials. By these means, donor factors that influence experimental or clinical findings can be made transparent and results are more comparable. Moreover, this knowledge can be used for study design to form a homogenous donor cohort by precise clinical history and physical examination.

  • Lipedema and the Evolution to Lymphedema With the Progression of Obesity
    by Lívia Maria Pereira de Godoy on 7 de dezembro de 2020 at 11:00

    CONCLUSION: Patients with lipedema can develop edema even when their weight is within the standards of normality. However, obesity is an aggravating factor, as the prevalence of lipedema increases progressively with the increase in weight.

  • Physiotherapy and rehabilitation applications in lipedema management: A literature review
    by M Esmer on 15 de novembro de 2020 at 11:00

    Lipedema is a chronic and progressive disease of adipose tissue caused by abnormal fat accumulation in subcutaneous tissue. Although there is no known cure for lipedema, possible complications can be prevented with conservative and surgical treatments. One of the conservative treatment options is physiotherapy and rehabilitation (PR). When the literature is examined, few studies focusing on the efficacy of PR were found for this patient group. The purpose of this review is to provide a better…