lipedema rss lipedema rss: Latest results from PubMed
- Reply letter to the editor regarding ultrasound examination for en-suite measurements in lipedemaby Alexandre Cm Amato on 4 de maio de 2022 at 10:00
- 3D Visualization of Human Blood Vascular Networks Using Single-Domain Antibodies Directed against Endothelial Cell-Selective Adhesion Molecule (ESAM)by Nils Rouven Hansmeier on 23 de abril de 2022 at 10:00
High-quality three-dimensional (3D) microscopy allows detailed, unrestricted and non-destructive imaging of entire volumetric tissue specimens and can therefore increase the diagnostic accuracy of histopathological tissue analysis. However, commonly used IgG antibodies are oftentimes not applicable to 3D imaging, due to their relatively large size and consequently inadequate tissue penetration and penetration speed. The lack of suitable reagents for 3D histopathology can be overcome by an…
- Exploring disease interrelationships in patients with lymphatic disorders: A single center retrospective experienceby Stanley G Rockson on 22 de abril de 2022 at 10:00
CONCLUSIONS: The presence or absence of a lymphatic disease significantly influences disease interrelationships in the study cohorts. As a physiologic substrate, the lymphatic circulation may be an underappreciated participant in disease pathogenesis. These relationships warrant further, prospective scrutiny and study.
- Capillary Western Immunoassay Optimization of Estrogen Related Factors in Human Subcutaneous Adipose Tissueby Jessica L Hill on 21 de abril de 2022 at 10:00
Lipedema is a multifaceted chronic fat disorder characterized by the bilateral and disproportionate accumulation of fat predominantly in the lower body regions of females. Research strongly supports that estrogen factors likely contribute to the pathophysiology of this disease. We aim to help demonstrate this link by quantifying estrogen factor differences between women with and without lipedema. For time and lipedema adipose tissue conservation, the Protein Simple WES machine will be utilized…
- Hypotheses and Evolution in the Current Treatment of Lipedema Syndromeby Jose Maria Pereira de Godoy on 23 de março de 2022 at 10:00
- What do lymphedema patients expect from a treatment and what do they achieve? A descriptive studyby Elif Duygu Yildiz on 15 de março de 2022 at 10:00
CONCLUSIONS: It is important to identify patients’ needs and expectations. Patients should be referred for treatment according to their needs. The effectiveness of the treatment should be evaluated objectively. Patient education should be considered as a part of the effective treatment to teach patients how to control their lymphedema. A clear diagnosis and access to treatment should be ensured for lymphedema patients. Regulations for health insurance benefit coverage are needed to cover cost of…
- A Multi-Gene Panel to Identify Lipedema-Predisposing Genetic Variants by a Next-Generation Sequencing Strategyby Sandro Michelini on 25 de fevereiro de 2022 at 11:00
Lipedema is a disabling disease characterized by symmetric enlargement of the lower and/or upper limbs due to deposits of subcutaneous fat, that is easily misdiagnosed. Lipedema can be primary or syndromic, and can be the main feature of phenotypically overlapping disorders. The aim of this study was to design a next-generation sequencing (NGS) panel to help in the diagnosis of lipedema by identifying genes specific for lipedema but also genes for overlapping diseases, and targets for tailored…
- Persistent lipedema pain in patients after bariatric surgery: a case series of 13 patientsby Manuel E Cornely on 11 de fevereiro de 2022 at 11:00
CONCLUSIONS: Because of the different etiologies of lipedema and obesity, lipedema requires its own specific treatment. Patients suffering from obesity should always be assessed for pain and lipedema. If coincident lipedema is diagnosed, we suggest that bariatric surgery only be performed first if diet and exercise have failed, the patient’s body mass index is >40 kg/m², and the patient has been informed of the possible persistence of pain. Lipedema, like a coincident disease, must be…
- Using a Patient Portal to Increase Enrollment in a Newborn Screening Research Study: Observational Studyby Lisa M Gehtland on 10 de fevereiro de 2022 at 11:00
CONCLUSIONS: Patient portals are an effective way to recruit participants for research studies, but there are substantial racial and ethnic disparities and disparities by urban/rural status in the use of patient portals, the opening of a patient portal invitation, and enrollment in the study.
- A 10-Year Retrospective before-and-after Study of Lipedema Surgery: Patient-Reported Lipedema-Associated Symptom Improvement after Multistage Liposuctionby Philipp Kruppa on 28 de janeiro de 2022 at 11:00
CONCLUSION: Liposuction reduces the severity of symptoms and the need for conservative treatment in lipedema patients, especially if it is performed in patients with a body mass index below 35 kg/m2 at an early stage of the disease.
- Prevalence of clinical manifestations and orthopedic alterations in patients with lipedema: A prospective cohort studyby I Forner-Cordero on 24 de janeiro de 2022 at 11:00
Lipedema is a chronic disease seen frequently in women that causes abnormal fat deposition in the lower limbs and associated bruising and pain. Despite increasing knowledge concerning lipedema, there are still aspects of diagnosis that need further investigation. We performed a prospective, observational cohort study to describe prevalence of clinical characteristics present in patients with lipedema in an attempt to establish diagnostic criteria. Participants were consecutive patients with…
- Ultrasound examination for en-suite measurements in lipedemaby Orhan Güvener on 4 de janeiro de 2022 at 11:00
- Lipedemaby Ankit Vyas on 1 de janeiro de 2022 at 11:00
Dr. Allen and Dr. Hines pioneered and first described lipedema in the 1940s, a common subcutaneous adipose tissue disorder characterized as enlargement of both lower extremities. Lipedema is not edema; it is a genetically determined disturbance in adipose tissue mass and adipose tissue distribution. In 1951 a second seminal paper provided more description of lipedema. Fat distribution involves lower extremities, upper arms, hips, buttocks, thighs sparing trunks, and feet. Lower extremities are…
- Management of Lipedema with Ketogenic Diet: 22-Month Follow-Upby Roberto Cannataro on 24 de dezembro de 2021 at 11:00
Lipedema is a pathology of adipose tissue, still of unclear etiology and challenging to diagnose. For these reasons, a therapeutic approach is also complex and sometimes controversial. The inflammation state present in lipedema can be limited by controlling the glycemic peaks. Specifically, the ketogenic diet (KD) seems to have the right conditions to be effective. Herein, we reported a subject diagnosed with lipedema who, with only KD nutritional intervention, achieved a significant weight loss…
- Indocyanine green lymphography as novel tool to assess lymphatics in patients with lipedemaby Giacomo Buso on 13 de dezembro de 2021 at 11:00
CONCLUSIONS: Present study suggests that lymphatic functioning in patients with lipedema correlates with symptoms duration. Further research on larger cohorts should verify our findings and clarify their potential therapeutic implications. Overall, ICG lymphography may be promising technique to assess both lymphatic anatomy and functioning in patients with lipedema.
- Lipedema Can Be Treated Non-Surgically: A Report of 5 Casesby Alexandre Campos Moraes Amato on 6 de dezembro de 2021 at 11:00
BACKGROUND Lipedema is a chronic progressive disease characterized by the abnormal accumulation of fat in the subcutaneous region. Both medical and surgical treatments have been described in international guidelines; however, the current literature is biased toward promoting liposuction as the primary treatment of lipedema, and this can lead to the misapprehension that liposuction is the only form of definitive treatment. CASE REPORT In the present study, we report 5 cases at various stages of…
- Lipedema and the Potential Role of Estrogen in Excessive Adipose Tissue Accumulationby Kaleigh Katzer on 13 de novembro de 2021 at 11:00
Lipedema is a painful fat disorder that affects ~11% of the female population. It is characterized by bilateral, disproportionate accumulation of subcutaneous adipose tissue predominantly in the lower body. The onset of lipedema pathophysiology is thought to occur during periods of hormonal fluctuation, such as puberty, pregnancy, or menopause. Although the identification and characterization of lipedema have improved, the underlying disease etiology remains to be elucidated. Estrogen, a key…
- Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedemaby Musarat Ishaq on 12 de novembro de 2021 at 11:00
CONCLUSION: We found significant differences in gene expression, and lipid and metabolite profiles, in tissue, ADSCs, and adipocytes from lipedema patients compared to non-affected controls. Functional assays demonstrated that dysregulated Bub1 signaling drives increased proliferation of lipedema ADSCs, suggesting a potential mechanism for enhanced adipogenesis in lipedema. Importantly, our characterization of signaling networks driving lipedema identifies potential molecular targets, including…
- Physical Therapy in Women with Early Stage Lipedema: Potential Impact of Multimodal Manual Therapy, Compression, Exercise, and Education Interventionsby Paula M C Donahue on 8 de novembro de 2021 at 11:00
Background: Lipedema is a distinct adipose disorder from obesity necessitating awareness as well as different management approaches to address pain and optimize quality of life (QoL). The purpose of this proof-of-principle study is to evaluate the therapeutic potential of physical therapy interventions in women with lipedema. Methods and Results: Participants with Stage 1-2 lipedema and early Stage 0-1 lymphedema (n = 5, age = 38.4 ± 13.4 years, body mass index = 27.2 ± 4.3 kg/m²) underwent nine…
- A randomised controlled multicentre investigator-blinded clinical trial comparing efficacy and safety of surgery versus complex physical decongestive therapy for lipedema (LIPLEG)by Maurizio Podda on 31 de outubro de 2021 at 10:00
BACKGROUND: Lipedema is a chronic disorder of the adipose tissue that affects mainly women, characterised by symmetrical, excessive fatty tissue on the legs and pain. Standard conservative treatment is long-term comprehensive decongestive therapy (CDT) to alleviate lipedema-related pain and to improve psychosocial well-being, mobility and physical activity. Patients may benefit from surgical removal of abnormally propagated adipose tissue by liposuction. The LIPLEG trial evaluates the efficacy…
- Crosstalk Between Adipose and Lymphatics in Health and Diseaseby Gregory P Westcott on 31 de outubro de 2021 at 10:00
Adipose tissue, once thought to be an inert receptacle for energy storage, is now recognized as a complex tissue with multiple resident cell populations that actively collaborate in response to diverse local and systemic metabolic, thermal, and inflammatory signals. A key participant in adipose tissue homeostasis that has only recently captured broad scientific attention is the lymphatic vasculature. The lymphatic system’s role in lipid trafficking and mediating inflammation makes it a natural…
- Elevated magnetic resonance imaging measures of adipose tissue deposition in women with breast cancer treatment-related lymphedemaby Rachelle Crescenzi on 23 de outubro de 2021 at 10:00
CONCLUSION: Adiposity quantified by MRI is elevated in the affected upper extremity of women with BCRL and may provide a surrogate marker of condition onset or severity.
- Unique functions for Notch4 in murine embryonic lymphangiogenesisby Ajit Muley on 19 de outubro de 2021 at 10:00
In mice, embryonic dermal lymphatic development is well understood and used to study gene functions in lymphangiogenesis. Notch signaling is an evolutionarily conserved pathway that modulates cell fate decisions, which has been shown to both inhibit and promote dermal lymphangiogenesis. Here, we demonstrate distinct roles for Notch4 signaling versus canonical Notch signaling in embryonic dermal lymphangiogenesis. Actively growing embryonic dermal lymphatics expressed NOTCH1, NOTCH4, and DLL4…
- Lipedema in a male patient: report of a rare case – management and review of the literatureby Mattis Bertlich on 18 de outubro de 2021 at 10:00
Objective: Lipedema is a relatively common yet debilitating and often misdiagnosed lipodystrophy that mainly affects females. Very little is known about the etiology and pathophysiology of the disease. However, due to its high preference for female patients, hormonal factors may contribute to the pathogenesis. Case: A 62-year-old male patient presented to the authors with painful swelling of the thighs. The patient had been treated elsewhere for lymphedema with subsequent disease progression….
- Lipoedema as a Social Problem. A Scoping Reviewby Monika Czerwińska on 13 de outubro de 2021 at 10:00
(1) Background: Lipoedema is a disease characterized by excessive bilateral and symmetrical accumulation of subcutaneous tissue in the lower extremities. It is a poorly understood condition, and low awareness of its existence often leads to incorrect diagnosis Initially, lipoedema was considered to be completely independent of lifestyle Currently, however, more and more cases of the coexistence of lipoedema and obesity are described in the literature as additionally affecting the severity of the…
- Common and Contrasting Characteristics of the Chronic Soft-Tissue Pain Conditions Fibromyalgia and Lipedemaby Felix Angst on 24 de setembro de 2021 at 10:00
OBJECTIVE: To examine the common and specific characteristics of fibromyalgia and lipedema, two chronic soft-tissue pain syndromes without curative therapy options.
- JUXTA-ARTICULAR ADIPOSIS DOLOROSA IN LIPEDEMA PATIENTSby U Wollina on 13 de setembro de 2021 at 10:00
Both lipedema and juxta-articular adiposis dolorsa are painful disorders of subcutaneous adipose tissue. We investigated 297 female patients with lipedema treated at our department for the presence of juxta-articular adiposis dolorsa. Occurrence of both disorders was identified in 4.4% of lipedema patients. The common presence of both disorders was observed only in more advanced lipedema (grade II and III). Juxta-articular adiposis dolorosa of the knees is seen exclusively on the inner knees,…
- Regression of lipoedematous scalp following cryolipolysis using an icepack, with a novel dermoscopic feature of yellow backgroundby V Kharkar on 18 de agosto de 2021 at 10:00
The novel use of cryolipolysis via icepacks, a readily available and inexpensive device, is described for lipoedematous scalp with subjective and objective relief. This is a simple solution to a troublesome, intractable condition and may readily be utilized for patient benefit. Juxtaposing pre and post clinical images.
- The association between serum vitamin D and mood disorders in a cohort of lipedema patientsby Mohammad Al-Wardat on 29 de julho de 2021 at 10:00
CONCLUSIONS: This study suggests a strong correlation between Vit. D levels, depression scores, and anxiety scores in lipedema patients. Our results also demonstrate a strong and direct relationship between BMI, Vit. D levels, depression, and anxiety.
- Leg Volume in Patients with Lipoedema following Bariatric Surgeryby Jodok M Fink on 12 de julho de 2021 at 10:00
CONCLUSION: SG and RYGB lead to a significant thigh volume reduction in patients with lipoedema.
- Women’s experiences of living with lipedemaby Catharina Melander on 12 de julho de 2021 at 10:00
Lipedema is a chronic, progressive disease that almost exclusively affects women and often misdiagnosed as obesity or primary lymphedema. Research concerning lipedema is sparse, and there is a lack of studies focusing on women’s experiences of living with the illness. We interviewed fourteen women with lipedema with the aim of describing their experiences of living with lipedema. Our results show that women felt controlled by their body, and were fat-shamed and viewed by others as a person who…
- Development of a questionnaire and screening model for lipedemaby Alexandre Campos Moraes Amato on 2 de julho de 2021 at 10:00
CONCLUSIONS: The lipedema screening questionnaire is a practical instrument that is quick and easy to administer and can be used with our population for identification of possible lipedema patients, raising the level of suspicion when taking a patient’s history and conducting a physical examination.
- Lipoedema – diagnosis, treatment, and experiences: A systematic review and assessment of medical, economic and ethical aspects [Internet]on 1 de julho de 2021 at 10:00
The aim of this report is to assess the scientific evidence with respect to the diagnosis and treatment of lipoedema, experiences and perceptions of those who have lipoedema regarding their care and support when interacting with healthcare, health economics, and ethical aspects.
- Translation, cultural adaptation, and validation of a lipedema symptoms questionnaireby Alexandre Campos Moraes Amato on 28 de junho de 2021 at 10:00
CONCLUSIONS: The translated and culturally adapted Brazilian Portuguese version of the lipedema symptoms assessment questionnaire (QuASiL) is a practical tool that is easy and quick to administer and can be used in our population. Additional studies are still needed to assess the instrument’s sensitivity as an aid for diagnosis of lipedema.
- A Young Woman with Excessive Fat in Lower Extremities Develops Disordered Eating and Is Subsequently Diagnosed with Anorexia Nervosa, Lipedema, and Hypermobile Ehlers-Danlos Syndromeby Thomas F Wright on 14 de junho de 2021 at 10:00
BACKGROUND Lipedema is a loose connective tissue disease that causes disproportionate subcutaneous fat accumulation on the extremities. As a result of the increased subcutaneous tissue accumulation, lipedema is often confused with obesity by both physicians and patients. Poor awareness and limited diagnosis of lipedema contribute to the confusion of lipedema with obesity and can lead to decreased body image acceptance. Patients with lipedema may have anorexia nervosa, an eating disorder…
- Standard of care for lipedema in the United Statesby Karen L Herbst on 29 de maio de 2021 at 10:00
CONCLUSION: These guidelines improve the understanding of the loose connective tissue disease, lipedema, to advance our understanding towards early diagnosis, treatments, and ultimately a cure for affected individuals.
- A 41-Year-Old Woman with Excessive Fat of the Lower Body Since Puberty with Progression to Swollen Ankles and Feet Despite Caloric Restriction, Due to Lipedema and Protein-Calorie Malnutrition: A Case of Stage 3 Lipedemaby Thomas F Wright on 7 de maio de 2021 at 10:00
BACKGROUND Lipedema is a common condition that presents as excessive fat deposition in the extremities, initially sparing the trunk, ankles, and feet, and is found mainly in women, usually occurring after puberty or pregnancy. Lipedema can progress to include lipo-lymphedema of the ankles and feet. This report is of a 41-year old woman with Stage 3 lipedema and lipo-lymphedema with excessive fat of the lower body since puberty, with progression to swollen ankles and feet despite dietary caloric…
- Liposuction treatment improves disease-specific quality of life in lipoedema patientsby Torsten Schlosshauer on 6 de maio de 2021 at 10:00
This study examined the disease-specific quality of life (QoL) in lipoedema patients undergoing treatment for the condition with liposuction. We conducted a retrospective analysis of all patients (n = 69) who underwent liposuction for treatment of lipoedema between 2004 and 2019, and gathered data on patient age, body mass index, the number of liposuction sessions, and the amount of fat removed per side. The study also prospectively evaluated the QoL in 20 lipoedema patients before and after…
- Survey Outcomes of Lipedema Reduction Surgery in the United Statesby Karen L Herbst on 29 de abril de 2021 at 10:00
CONCLUSIONS: Women with lipedema noticed significant benefits after lipedema reduction surgery in the USA. Prospective studies are needed to assess benefits and complications after lipedema reduction surgery in the USA.
- Choroid plexus perfusion in sickle cell disease and moyamoya vasculopathy: Implications for glymphatic flowby Skylar E Johnson on 28 de abril de 2021 at 10:00
Cerebrospinal fluid (CSF) and interstitial fluid exchange have been shown to increase following pharmacologically-manipulated increases in cerebral arterial pulsatility, consistent with arterial pulsatility improving CSF circulation along perivascular glymphatic pathways. The choroid plexus (CP) complexes produce CSF, and CP activity may provide a centralized indicator of perivascular flow. We tested the primary hypothesis that elevated cortical cerebral blood volume and flow, present in sickle…
- Correction to: The Effects of Complex Decongestive Physiotherapy Applications on Lower Extremity Circumference and Volume in Patients with Lipedema by Volkan-Yazıcı, et al. Lymphat Res Biol 2021;19(1):111-114; DOI: 10.1089/lrb.2020.0080on 26 de abril de 2021 at 10:00
- Update in the management of lipedemaby Isabel Forner-Cordero on 19 de abril de 2021 at 10:00
CONCLUSIONS: The setting of realistic expectations is important for both patient and medical care provider. The major aims of the management are multimodal for improvements in the quality of life; reduction in heaviness and pain, reshaping the affected limbs, weight control, improvements in mobility. Compression garments, physical therapy, exercise regimens, diet and psychological counseling are necessities. For selected patients, surgical treatment is an added option.
- Ultrasound criteria for lipedema diagnosisby Alexandre Campos Moraes Amato on 15 de abril de 2021 at 10:00
CONCLUSIONS: Studied criteria allow use of simple and reproducible ultrasound cutoff values to diagnose lipedema in the lower limbs. Pre-tibial region thickness measurement, followed by thigh and lateral leg thickness are recommended for the ultrasound diagnosis of lipedema.
- Management of large volume liposuction in lipedema patients with von Willebrand disease: A systematic review and treatment algorithmby Jeremias Schmidt on 5 de abril de 2021 at 10:00
CONCLUSION: The implementation of the developed diagnostic and treatment algorithm may help further reducing bleeding complications and improve the safety for treated patients.
- A Distinct Cytokine Profile and Stromal Vascular Fraction Metabolic Status without Significant Changes in the Lipid Composition Characterizes Lipedemaby Stefan Wolf on 3 de abril de 2021 at 10:00
Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat tissue in the lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish the disease exist, leading to a large number of undiagnosed and misdiagnosed patients. To unravel the distinct molecular characteristic of lipedema we performed lipidomic analysis of the adipose tissue and serum of lipedema versus anatomically- and body mass…
- Reducing Circumference and Volume in Upper Extremity Lipedema: The Role of Complex Decongestive Physiotherapyby Melek Volkan-Yazici on 2 de abril de 2021 at 10:00
Objective: The aim of this study is to investigate the effect of complex decongestive physiotherapy (CDP) plus intermittent pneumatic compression (IPC) applications on upper extremity circumference and volume in patients with lipedema. Methods and Results: All participants included in the study were included in a treatment protocol consisting of CDP and IPC. The Perometer 400 NT was used in the measurement of upper extremity volume and circumference before and after treatment. The measurements…
- Lipedema : an unknown entityby Vincienne Naef on 1 de abril de 2021 at 10:00
Lipedema is an infrequently recognized disorder. It is characterized by bilateral painful enlargement of the legs due to abnormal depositions of subcutaneous fat, that can result in considerable disability. The diagnosis is established on the basis of medical history and clinical findings. Early diagnosis of this disorder is necessary to start adapted management and prevent progression and complications of the disease. Currently there is no curative treatment. The conservative treatment requires…
- Interstitial Fluid in Lipedema and Control Skinby Marisol Allen on 31 de março de 2021 at 10:00
Background: Fluid in lymphedema tissue appears histologically as spaces around vessels and between dermal skin fibers. Lipedema is a painful disease of excess loose connective tissue (fat) in limbs, almost exclusively of women, that worsens by stage, increasing lymphedema risk. Many women with lipedema have hypermobile joints suggesting a connective tissue disorder that may affect vessel structure and compliance of tissue resulting in excess fluid entering the interstitial space. It is unclear…
- The Prevalence Was Probably Overestimatedby Ulrich Herpertz on 24 de março de 2021 at 10:00
- Stemmer Sign Needs to be Recorded and Interpreted Correctlyby Wolfgang Justus Brauer on 24 de março de 2021 at 10:00