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Lipedema papers lipedema – Search Results – PubMed

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Lipedema: exploring pathophysiology and treatment strategies – state of the art
    by Fabio Kamamoto on 27 de janeiro de 2025 at 11:00

    J Vasc Bras. 2025 Jan 20;23:e20240025. doi: 10.1590/1677-5449.202400252. eCollection 2024.ABSTRACTLipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional interventions such as diet and exercise. Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. This narrative review provides a deeper understanding of lipedema treatment, addressing pathophysiology and therapeutic options. The data reveal advances in knowledge, especially regarding conservative and surgical treatments, focusing on improving quality of life. However, scientific evidence supporting the safety and efficacy of various treatments is lacking. Additional research is needed to ensure safety and to enhance efficacy of management of this complex condition.PMID:39866170 | PMC:PMC11758576 | DOI:10.1590/1677-5449.202400252

  • Is lipedema a progressive disease?
    by Isabel Forner-Cordero on 20 de janeiro de 2025 at 11:00

    Vasc Med. 2025 Jan 20:1358863X241306415. doi: 10.1177/1358863X241306415. Online ahead of print.ABSTRACTBACKGROUND: It is not yet known whether lipedema is a progressive chronic disease or not. The aim of this paper is to describe the long-term changes in the volume of the lower limbs.METHODS: The primary endpoint of this prospective cohort study of patients with lipedema was the percentage of volume change (PVC) during follow up. Progression was defined as when the PVC was > 10% from the baseline, whereas improvement was defined as when the PVC was < -10%, and stability as PVC -10% to 10%.RESULTS: A cohort of 100 patients with lipedema were included in the study. The average follow-up period from the start of this study was 4.6 years. The average PVC was 2.8%. Stability was observed in 62% of the patients, progression in 28%, and improvement in 10%. In the univariate analysis, a significant positive association was observed between PVC and both BMI-change and waist-to-height ratio (WHtR)-change. The more the BMI increased, the more the lipedema progressed (p < 0.0001), as did the WHtR (p < 0.0001). In the adjusted regression analysis, age was not seen to be an influencing factor for PVC. Regarding maintenance therapies, no associations were observed.CONCLUSION: Lipedema was seen to be stable in two-thirds of the patients. Age was not related to progression. Progression was related to WHtR increase, which is an indicator of abdominal fat gain. This demonstrates the relationship between fat gain and lipedema progression.PMID:39831319 | DOI:10.1177/1358863X241306415

  • Is lipedema a progressive disease?
    by Isabel Forner-Cordero on 20 de janeiro de 2025 at 11:00

    Vasc Med. 2025 Jan 20:1358863X241306415. doi: 10.1177/1358863X241306415. Online ahead of print.ABSTRACTBACKGROUND: It is not yet known whether lipedema is a progressive chronic disease or not. The aim of this paper is to describe the long-term changes in the volume of the lower limbs.METHODS: The primary endpoint of this prospective cohort study of patients with lipedema was the percentage of volume change (PVC) during follow up. Progression was defined as when the PVC was > 10% from the baseline, whereas improvement was defined as when the PVC was < -10%, and stability as PVC -10% to 10%.RESULTS: A cohort of 100 patients with lipedema were included in the study. The average follow-up period from the start of this study was 4.6 years. The average PVC was 2.8%. Stability was observed in 62% of the patients, progression in 28%, and improvement in 10%. In the univariate analysis, a significant positive association was observed between PVC and both BMI-change and waist-to-height ratio (WHtR)-change. The more the BMI increased, the more the lipedema progressed (p < 0.0001), as did the WHtR (p < 0.0001). In the adjusted regression analysis, age was not seen to be an influencing factor for PVC. Regarding maintenance therapies, no associations were observed.CONCLUSION: Lipedema was seen to be stable in two-thirds of the patients. Age was not related to progression. Progression was related to WHtR increase, which is an indicator of abdominal fat gain. This demonstrates the relationship between fat gain and lipedema progression.PMID:39831319 | DOI:10.1177/1358863X241306415

  • Is lipedema a progressive disease?
    by Isabel Forner-Cordero on 20 de janeiro de 2025 at 11:00

    Vasc Med. 2025 Jan 20:1358863X241306415. doi: 10.1177/1358863X241306415. Online ahead of print.ABSTRACTBACKGROUND: It is not yet known whether lipedema is a progressive chronic disease or not. The aim of this paper is to describe the long-term changes in the volume of the lower limbs.METHODS: The primary endpoint of this prospective cohort study of patients with lipedema was the percentage of volume change (PVC) during follow up. Progression was defined as when the PVC was > 10% from the baseline, whereas improvement was defined as when the PVC was < -10%, and stability as PVC -10% to 10%.RESULTS: A cohort of 100 patients with lipedema were included in the study. The average follow-up period from the start of this study was 4.6 years. The average PVC was 2.8%. Stability was observed in 62% of the patients, progression in 28%, and improvement in 10%. In the univariate analysis, a significant positive association was observed between PVC and both BMI-change and waist-to-height ratio (WHtR)-change. The more the BMI increased, the more the lipedema progressed (p < 0.0001), as did the WHtR (p < 0.0001). In the adjusted regression analysis, age was not seen to be an influencing factor for PVC. Regarding maintenance therapies, no associations were observed.CONCLUSION: Lipedema was seen to be stable in two-thirds of the patients. Age was not related to progression. Progression was related to WHtR increase, which is an indicator of abdominal fat gain. This demonstrates the relationship between fat gain and lipedema progression.PMID:39831319 | DOI:10.1177/1358863X241306415

  • Is lipedema a progressive disease?
    by Isabel Forner-Cordero on 20 de janeiro de 2025 at 11:00

    Vasc Med. 2025 Jan 20:1358863X241306415. doi: 10.1177/1358863X241306415. Online ahead of print.ABSTRACTBACKGROUND: It is not yet known whether lipedema is a progressive chronic disease or not. The aim of this paper is to describe the long-term changes in the volume of the lower limbs.METHODS: The primary endpoint of this prospective cohort study of patients with lipedema was the percentage of volume change (PVC) during follow up. Progression was defined as when the PVC was > 10% from the baseline, whereas improvement was defined as when the PVC was < -10%, and stability as PVC -10% to 10%.RESULTS: A cohort of 100 patients with lipedema were included in the study. The average follow-up period from the start of this study was 4.6 years. The average PVC was 2.8%. Stability was observed in 62% of the patients, progression in 28%, and improvement in 10%. In the univariate analysis, a significant positive association was observed between PVC and both BMI-change and waist-to-height ratio (WHtR)-change. The more the BMI increased, the more the lipedema progressed (p < 0.0001), as did the WHtR (p < 0.0001). In the adjusted regression analysis, age was not seen to be an influencing factor for PVC. Regarding maintenance therapies, no associations were observed.CONCLUSION: Lipedema was seen to be stable in two-thirds of the patients. Age was not related to progression. Progression was related to WHtR increase, which is an indicator of abdominal fat gain. This demonstrates the relationship between fat gain and lipedema progression.PMID:39831319 | DOI:10.1177/1358863X241306415

  • Is lipedema a progressive disease?
    by Isabel Forner-Cordero on 20 de janeiro de 2025 at 11:00

    Vasc Med. 2025 Jan 20:1358863X241306415. doi: 10.1177/1358863X241306415. Online ahead of print.ABSTRACTBACKGROUND: It is not yet known whether lipedema is a progressive chronic disease or not. The aim of this paper is to describe the long-term changes in the volume of the lower limbs.METHODS: The primary endpoint of this prospective cohort study of patients with lipedema was the percentage of volume change (PVC) during follow up. Progression was defined as when the PVC was > 10% from the baseline, whereas improvement was defined as when the PVC was < -10%, and stability as PVC -10% to 10%.RESULTS: A cohort of 100 patients with lipedema were included in the study. The average follow-up period from the start of this study was 4.6 years. The average PVC was 2.8%. Stability was observed in 62% of the patients, progression in 28%, and improvement in 10%. In the univariate analysis, a significant positive association was observed between PVC and both BMI-change and waist-to-height ratio (WHtR)-change. The more the BMI increased, the more the lipedema progressed (p < 0.0001), as did the WHtR (p < 0.0001). In the adjusted regression analysis, age was not seen to be an influencing factor for PVC. Regarding maintenance therapies, no associations were observed.CONCLUSION: Lipedema was seen to be stable in two-thirds of the patients. Age was not related to progression. Progression was related to WHtR increase, which is an indicator of abdominal fat gain. This demonstrates the relationship between fat gain and lipedema progression.PMID:39831319 | DOI:10.1177/1358863X241306415

  • Is lipedema a progressive disease?
    by Isabel Forner-Cordero on 20 de janeiro de 2025 at 11:00

    Vasc Med. 2025 Jan 20:1358863X241306415. doi: 10.1177/1358863X241306415. Online ahead of print.ABSTRACTBACKGROUND: It is not yet known whether lipedema is a progressive chronic disease or not. The aim of this paper is to describe the long-term changes in the volume of the lower limbs.METHODS: The primary endpoint of this prospective cohort study of patients with lipedema was the percentage of volume change (PVC) during follow up. Progression was defined as when the PVC was > 10% from the baseline, whereas improvement was defined as when the PVC was < -10%, and stability as PVC -10% to 10%.RESULTS: A cohort of 100 patients with lipedema were included in the study. The average follow-up period from the start of this study was 4.6 years. The average PVC was 2.8%. Stability was observed in 62% of the patients, progression in 28%, and improvement in 10%. In the univariate analysis, a significant positive association was observed between PVC and both BMI-change and waist-to-height ratio (WHtR)-change. The more the BMI increased, the more the lipedema progressed (p < 0.0001), as did the WHtR (p < 0.0001). In the adjusted regression analysis, age was not seen to be an influencing factor for PVC. Regarding maintenance therapies, no associations were observed.CONCLUSION: Lipedema was seen to be stable in two-thirds of the patients. Age was not related to progression. Progression was related to WHtR increase, which is an indicator of abdominal fat gain. This demonstrates the relationship between fat gain and lipedema progression.PMID:39831319 | DOI:10.1177/1358863X241306415