lipedema rss lipedema rss: Latest results from PubMed

  • Ultrasound criteria for lipedema diagnosis
    by Alexandre Campos Moraes Amato on 15 de abril de 2021 at 10:00

    CONCLUSIONS: Studied criteria allow use of simple and reproducible ultrasound cutoff values to diagnose lipedema in the lower limbs. Pre-tibial region thickness measurement, followed by thigh and lateral leg thickness are recommended for the ultrasound diagnosis of lipedema.

  • Management of large volume liposuction in lipedema patients with von Willebrand disease: A systematic review and treatment algorithm
    by Jeremias Schmidt on 5 de abril de 2021 at 10:00

    CONCLUSION: The implementation of the developed diagnostic and treatment algorithm may help further reducing bleeding complications and improve the safety for treated patients.

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  • A Distinct Cytokine Profile and Stromal Vascular Fraction Metabolic Status without Significant Changes in the Lipid Composition Characterizes Lipedema
    by Stefan Wolf on 3 de abril de 2021 at 10:00

    Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat tissue in the lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish the disease exist, leading to a large number of undiagnosed and misdiagnosed patients. To unravel the distinct molecular characteristic of lipedema we performed lipidomic analysis of the adipose tissue and serum of lipedema versus anatomically- and body mass…

  • Reducing Circumference and Volume in Upper Extremity Lipedema: The Role of Complex Decongestive Physiotherapy
    by Melek Volkan-Yazici on 2 de abril de 2021 at 10:00

    Objective: The aim of this study is to investigate the effect of complex decongestive physiotherapy (CDP) plus intermittent pneumatic compression (IPC) applications on upper extremity circumference and volume in patients with lipedema. Methods and Results: All participants included in the study were included in a treatment protocol consisting of CDP and IPC. The Perometer 400 NT was used in the measurement of upper extremity volume and circumference before and after treatment. The measurements…

  • Dichotomous effects on lymphatic transport with loss of caveolae in mice
    by Gaurav Baranwal on 1 de abril de 2021 at 10:00

    CONCLUSION: Macromolecule transport across lymphatics is increased with loss of caveolae, yet phasic contractility reduced, resulting in reduced overall lymphatic transport function. These studies identify lymphatic caveolar biology as a key regulator of active lymphatic transport functions.

  • Lipedema : an unknown entity
    by Vincienne Naef on 1 de abril de 2021 at 10:00

    Lipedema is an infrequently recognized disorder. It is characterized by bilateral painful enlargement of the legs due to abnormal depositions of subcutaneous fat, that can result in considerable disability. The diagnosis is established on the basis of medical history and clinical findings. Early diagnosis of this disorder is necessary to start adapted management and prevent progression and complications of the disease. Currently there is no curative treatment. The conservative treatment requires…

  • Interstitial Fluid in Lipedema and Control Skin
    by Marisol Allen on 31 de março de 2021 at 10:00

    Background: Fluid in lymphedema tissue appears histologically as spaces around vessels and between dermal skin fibers. Lipedema is a painful disease of excess loose connective tissue (fat) in limbs, almost exclusively of women, that worsens by stage, increasing lymphedema risk. Many women with lipedema have hypermobile joints suggesting a connective tissue disorder that may affect vessel structure and compliance of tissue resulting in excess fluid entering the interstitial space. It is unclear…

  • The Prevalence Was Probably Overestimated
    by Ulrich Herpertz on 24 de março de 2021 at 10:00

    No abstract

  • Stemmer Sign Needs to be Recorded and Interpreted Correctly
    by Wolfgang Justus Brauer on 24 de março de 2021 at 10:00

    No abstract

  • Lipoedema: a paradigm shift and consensus. Has a consensus been achieved?
    by Leslyn Keith on 17 de março de 2021 at 10:00

    No abstract

  • Response from the authors…
    by Tobias Bertsch on 17 de março de 2021 at 10:00

    No abstract

  • High Volume Liposuction in Tumescence Anesthesia in Lipedema Patients: A Retrospective Analysis
    by Matthias Sandhofer on 8 de março de 2021 at 11:00

    Lipedema is a chronic, progressive disease that occurs almost exclusively in women and leads to pathological, painful fat growths at the extremities. Only symptomatic therapy can be offered since the etiology of the disease has not yet been clarified. Liposuction in tumescent anesthesia has established itself as a surgical treatment method of choice. The complication rate associated with the procedure and the pharmacological course and safety of treatment in patients with lipedema has not yet…

  • Rest/stress intradermal lymphoscintigraphy in diagnosis of lipedema
    by Girolamo Tartaglione on 24 de fevereiro de 2021 at 11:00

    Lipedema is a chronic and progressive disease characterized by a symmetrical and bilateral swelling of the lower extremities. In general, the feet are not involved. Lipedema is believed to affect nearly 1 in 9 adult women worldwide. Despite this relatively common disease, lipedema is often confused with primary lymphedema or obesity. In clinically advanced lipedema stages, fat continues to build up and may block the lymphatic vessels causing a secondary lymphedema (Lipo-Lymphedema). We…

  • Establishing Standards for Centers of Excellence for the Diagnosis and Treatment of Lymphatic Disease
    by David Chang on 5 de fevereiro de 2021 at 11:00

    Background: Lymphatic disease patients make up a significant proportion of the US and world populations. Due to inadequate medical school training and underestimation of the impact of lymphatic circulation, lymphatic disease patients often have difficulty finding competent diagnosis and care. Methods and Results: The Lymphatic Education & Research Network has initiated a Centers of Excellence program to designate institutions that provide services for lymphatic disease patients. Committees of…

  • Potential Effects of a Modified Mediterranean Diet on Body Composition in Lipoedema
    by Laura Di Renzo on 28 de janeiro de 2021 at 11:00

    Lipoedema is a subcutaneous adipose tissue disease characterized by the increase in the amount and structure of fat mass (FM) in specific areas, causing pain and discomfort. 95% of patients fail to lose weight in the lipoedema areas. The study was conducted to evaluate body composition and general health status modification in a group of lipoedema patients (LIPPY) and a control group (CTRL) after four weeks of a modified Mediterranean diet therapy (mMeD). A total of 29 subjects were included in…

  • Diagnosis and treatment of lipedema in Spain. Results of an online survey
    by E Vaquero Ramiro on 19 de janeiro de 2021 at 11:00

    CONCLUSIONS: Currently, there is no standard treatment for lipedema and patients perceive current treatments to be unsatisfactory. Better knowledge of this entity is needed to allow early diagnosis and provide adequate treatment.

  • Quality of life, its factors, and sociodemographic characteristics of Polish women with lipedema
    by Joanna E Dudek on 15 de janeiro de 2021 at 11:00

    CONCLUSIONS: The current study provides initial information on screening questions, lipedema symptoms, and comorbidities, pointing to the areas needing in-depth investigation. Further steps to improve quality of life in women with lipedema and to reduce health costs should include the education of medical health professionals, using diagnostic tools that allow for differentiation among diagnoses and precise health risk assessment, and creating Polish treatment guidelines for lipedema.

  • Primary lymphedema French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins)
    by Stéphane Vignes on 7 de janeiro de 2021 at 11:00

    Primary lymphedema is a rare chronic pathology associated with constitutional abnormalities of the lymphatic system. The objective of this French National Diagnosis and Care Protocol (Protocole National de Diagnostic et de Soins; PNDS), based on a critical literature review and multidisciplinary expert consensus, is to provide health professionals with an explanation of the optimal management and care of patients with primary lymphedema. This PNDS, written by consultants at the French National…

  • Unpreserved Lymphatic Reserve in Heart Failure With Preserved Ejection Fraction
    by Deepak K Gupta on 11 de dezembro de 2020 at 11:00

    No abstract

  • Ketogenic diet as a potential intervention for lipedema
    by L Keith on 11 de dezembro de 2020 at 11:00

    Lipedema (LI) is a common yet misdiagnosed condition, often misconstrued with obesity. LI affects women almost exclusively, and its painful and life-changing symptoms have long been thought to be resistant to the lifestyle interventions such as diet and exercise. In this paper, we discuss possible mechanisms by which patients adopting a ketogenic diet (KD) can alleviate many of the unwanted clinical features of LI. This paper is also an effort to provide evidence for the hypothesis of the…

  • The Effects of Complete Decongestive Therapy or Intermittent Pneumatic Compression Therapy or Exercise Only in the Treatment of Severe Lipedema: A Randomized Controlled Trial
    by Tuğba Atan on 10 de dezembro de 2020 at 11:00

    Background: Lack of diagnostic awareness of lipedema and frequent confusion with obesity or lymphedema may be an obstacle for treatment. The clinical effects of conservative treatment methods are not clearly known. This study investigated the effects of exercise-based rehabilitation combined with complete decongestive therapy (CDT) or intermittent pneumatic compression therapy (IPCT) or alone in patients with severe lipedema. Methods: Thirty-three women with severe (type 3, stage III or IV)…

  • Hematoma in lipedema: from cutaneous origin or defect of coagulation?
    by Christoph Sucker on 10 de dezembro de 2020 at 11:00

    Lipedema is a widespread in concern of etiology partially unknown disease especially in women. In many cases it is accompanied by bleeding complications. Our current work focuses on possible coagulation disorders as potential sources of such bleeding complications. Since only a minority of our patients showed a coagulation defect it is suggestive that the main underlying reason for bleeding in lipedema is of cutaneous origin what may only be forwarded by simultaneously existing coagulation…

  • Current review of factors in the stem cell donor that influence the regenerative potential of adipose tissue-derived stem cells
    by Constanze Kuhlmann on 8 de dezembro de 2020 at 11:00

    CONCLUSION: We recommend characterisation of the ASC donor cohort in all publications, regardless of whether they are experimental studies or clinical trials. By these means, donor factors that influence experimental or clinical findings can be made transparent and results are more comparable. Moreover, this knowledge can be used for study design to form a homogenous donor cohort by precise clinical history and physical examination.

  • Lipedema and the Evolution to Lymphedema With the Progression of Obesity
    by Lívia Maria Pereira de Godoy on 7 de dezembro de 2020 at 11:00

    CONCLUSION: Patients with lipedema can develop edema even when their weight is within the standards of normality. However, obesity is an aggravating factor, as the prevalence of lipedema increases progressively with the increase in weight.

  • Physiotherapy and rehabilitation applications in lipedema management: A literature review
    by M Esmer on 15 de novembro de 2020 at 11:00

    Lipedema is a chronic and progressive disease of adipose tissue caused by abnormal fat accumulation in subcutaneous tissue. Although there is no known cure for lipedema, possible complications can be prevented with conservative and surgical treatments. One of the conservative treatment options is physiotherapy and rehabilitation (PR). When the literature is examined, few studies focusing on the efficacy of PR were found for this patient group. The purpose of this review is to provide a better…

  • Disease progression and comorbidities in lipedema patients: A 10-year retrospective analysis
    by Mojtaba Ghods on 13 de novembro de 2020 at 11:00

    Multiple associated comorbidities have been described for lipedema patients. Disease diagnosis still remains challenging in many cases and is frequently delayed. The purpose of this study was to determine the most common comorbidities in lipedema patients and the impact of surgical treatment onto disease progression. A retrospective assessment of disease-related epidemiologic data was performed for patients who underwent liposuction between July 2009 and July 2019 in a specialized clinic for…

  • 3D Spheroids Derived from Human Lipedema ASCs Demonstrated Similar Adipogenic Differentiation Potential and ECM Remodeling to Non-Lipedema ASCs In Vitro
    by Sara Al-Ghadban on 11 de novembro de 2020 at 11:00

    The growth and differentiation of adipose tissue-derived stem cells (ASCs) is stimulated and regulated by the adipose tissue (AT) microenvironment. In lipedema, both inflammation and hypoxia influence the expansion and differentiation of ASCs, resulting in hypertrophic adipocytes and deposition of collagen, a primary component of the extracellular matrix (ECM). The goal of this study was to characterize the adipogenic differentiation potential and assess the levels of expression of…

  • Medical crowdfunding in a healthcare system with universal coverage: an exploratory study
    by Ágnes Lublóy on 10 de novembro de 2020 at 11:00

    CONCLUSIONS: In universal healthcare systems, medical crowdfunding is a viable option to finance alternative, complementary, experimental and scientifically poorly supported therapies not financed by the health insurance fund. Further analysis of the most common diseases and disorders listed in crowdfunding campaigns might provide guidance for national health insurance funds in extending their list of funded medical interventions. The fact of numerous individuals launching crowdfunding campaigns…

  • Lipoedema: a paradigm shift and consensus
    by Tobias Bertsch on 10 de novembro de 2020 at 11:00

    No abstract

  • Growth, body composition, and endocrine issues in Williams syndrome
    by Takara L Stanley on 9 de novembro de 2020 at 11:00

    PURPOSE OF REVIEW: Williams syndrome is a multisystem disorder caused by a microdeletion on chromosome 7q. Throughout infancy, childhood, and adulthood, abnormalities in body composition and in multiple endocrine axes may arise for individuals with Williams syndrome. This review describes the current literature regarding growth, body composition, and endocrine issues in Williams syndrome with recommendations for surveillance and management by the endocrinologist, geneticist, or primary care…

  • The Effects of Complex Decongestive Physiotherapy Applications on Lower Extremity Circumference and Volume in Patients with Lipedema
    by Melek Volkan-Yazıcı on 30 de outubro de 2020 at 10:00

    Background: The aim of this study is to investigate the effect of complex decongestive physiotherapy (CDP) plus intermittent pneumatic compression (IPC) applications on lower extremity limb circumference and volume in patients with lipedema. Methods and Results: In measurement of limb volume and circumference measurement, the Perometer 400 NT was used before and after treatment. The perometer measurements in this study were performed in the certain five reference points (cB, cC, cD, cE, and CF)….

  • The European Lipoedema Association
    by Rucha Kurtkoti on 8 de outubro de 2020 at 10:00

    No abstract

  • Use of upper-limb compression garments in the management of lipoedema
    by Rebecca Elwell on 8 de outubro de 2020 at 10:00

    Compression hosiery is commonly used for the management of lymphoedema as well as lipoedema, but it is more commonly indicated for the lower limbs than for the upper limbs. The effects of compression hosiery on upper-limb lipoedema are poorly understood and researched. It is known that compression hosiery works in conjunction with activity or movement when standing or walking, which produces anti-inflammatory and oxygenating effects in the tissues. This effect is naturally difficult to realise…

  • Cause and management of lipedema-associated pain
    by Hasan Aksoy on 1 de outubro de 2020 at 10:00

    Lipedema is a painful, underdiagnosed adipose tissue disorder, characterized by symmetrical swelling of the extremities due to subcutaneous fat deposition in the buttocks, thighs, legs, and arms, sparing the most distal part of the extremities. Although etiology and pathogenesis of lipedema is unclear, possible role of hormonal and genetic factors have been proposed previously. Patients with lipedema suffer from pain, easy bruising, tenderness, and disfigurement. Pain is the leading symptom in…

  • Lower extremity lymphatic function predicted by body mass index: a lymphoscintigraphic study of obesity and lipedema
    by Arin K Greene on 16 de setembro de 2020 at 10:00

    CONCLUSIONS: The risk of lymphedema in patients with obesity and lipedema can be predicted by BMI; confirmation requires lymphoscintigraphy. Individuals with OIL are at risk for cellulitis and MLL. Patients with a BMI > 40 are first managed with weight loss. Excisional procedures can further reduce extremity size once BMI has been lowered.

  • Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema
    by Sandro Michelini on 3 de setembro de 2020 at 10:00

    Lipedema is an often underdiagnosed chronic disorder that affects subcutaneous adipose tissue almost exclusively in women, which leads to disproportionate fat accumulation in the lower and upper body extremities. Common comorbidities include anxiety, depression, and pain. The correlation between mood disorder and subcutaneous fat deposition suggests the involvement of steroids metabolism and neurohormones signaling, however no clear association has been established so far. In this study, we…

  • Management of patients with lymphatic diseases and lipoedema during the COVID-19 pandemic. Recommendations of the Spanish Group of Lymphology
    by I Forner Cordero on 1 de setembro de 2020 at 10:00

    The COVID-19 pandemic poses a challenge to the management of non-COVID pathologies such as lymphatic diseases and lipoedema. The use of telemedicine can prevent the spread of the disease. A system is needed to help determine the clinical priority and selection of face-to-face or telemedicine options for each patient and how to carry them out during the pandemic. The Spanish Lymphology Group has drafted a consensus document with recommendations based on the literature and clinical experience, as…

  • Improvements in patients with lipedema 4, 8 and 12 years after liposuction
    by Axel Baumgartner on 28 de agosto de 2020 at 10:00

    CONCLUSION: The results show, that the positive effects of liposuction last 12 years postoperatively without relevant worsening. They imply that liposuction for lipedema leads to a permanent reduction of symptom severity and need for conservative therapy.

  • The MMP14-caveolin axis and its potential relevance for lipoedema
    by Ilja L Kruglikov on 15 de agosto de 2020 at 10:00

    Lipoedema is associated with widespread adipose tissue expansion, particularly in the proximal extremities. The mechanisms that drive the development of lipoedema are unclear. In this Perspective article, we propose a new model for the pathophysiology of lipoedema. We suggest that lipoedema is an oestrogen-dependent disorder of adipose tissue, which is triggered by a dysfunction of caveolin 1 (CAV1) and subsequent uncoupling of feedback mechanisms between CAV1, the matrix metalloproteinase MMP14…

  • Liposuction for Lipedema: Functional Therapy or Aesthetic Procedure?
    by Iakovos Georgiou on 14 de agosto de 2020 at 10:00

    Liposuction is one of the most common procedures undertaken in plastic surgery with a steadily increasing trend over the years. Although usually performed as an aesthetic procedure for body contouring, it can also be utilized in specific patient groups for disease symptom reduction. One such disease entity is lipedema. The goal of this video to present the authors’ technique in the surgical treatment of lipedema, and to offer the viewer a better understanding of the differences between an…

  • Lipedema-Pathogenesis, Diagnosis, and Treatment Options
    by Philipp Kruppa on 9 de agosto de 2020 at 10:00

    CONCLUSION: The diagnosis of lipedema remains a challenge because of the hetero – geneous presentation of the condition and the current lack of objective measuring instruments to characterize it. This review provides a guide to its diagnosis and treatment in an interdisciplinary setting. Research in this area should focus on the elucidation of the pathophysiology of lipedema and the development of a specific biomarker for it.

  • Cross-sectional validity and specificity of comprehensive measurement in lymphedema and lipedema of the lower extremity: a comparison of five outcome instruments
    by Felix Angst on 24 de julho de 2020 at 10:00

    CONCLUSIONS: All five instruments have specific strengths and can be implemented according to the scope and aim of the outcome examination. A minimum measurement set should comprise: the SF-36 Bodily pain, SF-36 Vitality, FLQA-lk Physical complaints, FLQA-lk Social life, FLQA-lk Emotional well-being, FLQA-lk Health state, KOS-ADL Symptoms, KOS-ADL Function, and the SCL-90R Interpersonal sensitivity.

  • Lipedematous scalp. A rare entity in the pediatric ageLipedema de cuero cabelludo: una entidad infrecuente en pediatría
    by Laura Míguez-Martín on 5 de julho de 2020 at 10:00

    Lipedematous scalp is an uncommon entity of unknown etiology, rarely described in the pediatric age. It is characterized by boggy thickening of the scalp predominantly located at the vertex and occiput, which acquires a cotton-like consistency. This condition is palpable rather than visible. It is a casual finding because it is usually asymptomatic, although it may involve alopecia, pruritus, or dysesthesia. We report a 10-year-old girl with lipedematous scalp without alopecia. Sonographic and…

  • Increased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology
    by Gunther Felmerer on 4 de julho de 2020 at 10:00

    Lipedema is a chronic adipose tissue disorder characterized by the disproportional subcutaneous deposition of fat and is commonly misdiagnosed as lymphedema or obesity. The molecular determinants of the lipedema remain largely unknown and only speculations exist regarding the lymphatic system involvement. The aim of the present study is to characterize the lymphatic vascular involvement in established lipedema. The histological and molecular characterization was conducted on anatomically-matched…

  • The impact of lower body compression garment on left ventricular rotational mechanics in patients with lipedema-Insights from the three-dimensional speckle tracking echocardiographic MAGYAR-Path Study
    by Attila Nemes on 24 de junho de 2020 at 10:00

    Lipedema is a lymphedema-masquerading symmetrical, bilateral and disproportional obesity. Its conservative maintenance treatment comprises the use of flat-knitted compression pantyhoses. Lipedema is known to be associated with left ventricular morphological and functional alterations. The present study aimed to assess the effects of graduated compression stockings on left ventricular (LV) rotational mechanics measured by three-dimensional speckle-tracking echocardiography (3DSTE) in lipedema…

  • Neuroimaging of Cerebral Blood Flow and Sodium in Women with Lipedema
    by Kalen J Petersen on 23 de junho de 2020 at 10:00

    CONCLUSIONS: Findings provide evidence that brain sodium and tissue fractions are similar between patients with lipedema and control participants and that patients with lipedema do not exhibit abnormal radiological indicators of intracranial vasculopathy or ischemic injury. Potential explanations for elevated CBF are discussed in the context of the growing literature on lipedema symptomatology and vascular dysfunction.

  • Extended overview of the longitudinal pain-depression association: A comparison of six cohorts treated for specific chronic pain conditions
    by Felix Angst on 21 de junho de 2020 at 10:00

    CONCLUSIONS: Moderate associations between changes in pain and depression levels were demonstrated across 5 of 6 different chronic pain conditions. The worse the pain and depression scores at baseline, the stronger those associations tended to be. Both findings indicate a certain dose-response relationship – an important characteristic of causal interference. Relieving pain by treatment may lead to the relief of depression and vice versa.

  • Non-contrast MR Lymphography of lipedema of the lower extremities
    by Michaela Cellina on 21 de junho de 2020 at 10:00

    CONCLUSION: NCMRL is a non-invasive imaging technique that is suitable for the evaluation of patients affected by lipedema and lipolymphedema, helping in the differential diagnosis.

  • Platelet factor 4 is a biomarker for lymphatic-promoted disorders
    by Wanshu Ma on 12 de junho de 2020 at 10:00

    Genetic or acquired defects of the lymphatic vasculature often result in disfiguring, disabling, and, occasionally, life-threatening clinical consequences. Advanced forms of lymphedema are readily diagnosed clinically, but more subtle presentations often require invasive imaging or other technologies for a conclusive diagnosis. On the other hand, lipedema, a chronic lymphatic microvascular disease with pathological accumulation of subcutaneous adipose tissue, is often misdiagnosed as obesity or…

  • Lipedema: A Commonly Misdiagnosed Fat Disorder
    by Marcelle Caruana on 28 de maio de 2020 at 10:00

    Lipedema is a fat disorder that is often misdiagnosed. It was first identified at the Mayo Clinic in 1940, but medical schools do not include it in their curriculum and is therefore poorly understood. It presents as disproportionate and symmetrical accumulations of fat (bilateral), which is often accompanied by orthostatic edema. Early diagnosis and treatment are crucial, as the disease is progressive and can lead to immobility as well as a significant decrease in the quality of life. Lipedema…